No. Any fees you pay to buy, sell, or hold an asset or to collect interest or dividends are not eligible for income tax deduction. This would include brokerage or transaction fees, management and advisor fees, custodial fees, accounting costs, and fund operating expenses.

Prior to the Tax Cuts and Jobs Act of 2017, you could itemize and deduct investment fees that were necessary to produce and collect taxable income if those deductions were greater than 2% of your adjusted gross income. Those deductions have been suspended through at least 2025.

If you itemize deductions, you may still be able to deduct investment interest expenses, which would mean any interest paid on money you borrowed to buy taxable investments.  A tax advisor can help you here since such advice always requires consideration of individual circumstances.